Study in Mice Finds Psilocybin May Protect Against Chemotherapy-Related Nerve Damage

A new study has found that psilocybin, the psychoactive compound found in so-called magic mushrooms, may help protect against nerve damage caused by chemotherapy, according to a report from Scientific American.

The findings, made in mice, point to a potential new approach for preventing a chemotherapy side effect known as peripheral neuropathy, which can cause pain, numbness and tingling in the hands and feet. According to the report, this condition is common among cancer patients undergoing chemotherapy and can persist long after treatment has ended.

Scientific American described the study as "unparalleled," though specific details about the mechanism by which psilocybin may offer this protective effect were not outlined in the available reporting.

The research remains in an early stage, having been conducted in mice rather than human subjects. It is not yet known whether the protective effects observed in animal models would translate to humans undergoing chemotherapy, or what dosing, timing or safety considerations might apply in a clinical context.

Psilocybin has been the subject of growing scientific interest in recent years for its potential therapeutic applications, including research into its effects on depression and other mental health conditions. This study adds a physical health application to that body of research, according to Scientific American's report.

Further research, including human clinical trials, would likely be needed before any conclusions could be drawn about psilocybin's potential use in preventing chemotherapy-induced nerve damage in cancer patients.