Jaxson Dart is set to undergo surgery believed to involve a meniscus and MCL repair, according to sources cited by ESPN.
Dart will undergo surgery and miss the rest of the regular season, though coach John Harbaugh left open the possibility of a playoff return.
ESPN's latest buzz roundup also examines running back depth charts in Tampa Bay and Carolina.
Dart's knee injury is more severe than originally believed, sources told NFL Network.
Los Angeles bounced back from its Week 1 loss while New York's night was marred by injuries to key players, including quarterback Jaxson Dart.
Initial exams suggest Giants quarterback Jaxson Dart sprained his MCL during Monday night's game, with an MRI scheduled to confirm the extent of the injury.
The rookie quarterback's ability to throw accurately from different angles has stood out, according to ESPN.
Dart is believed to have suffered a sprained MCL and will undergo an MRI Tuesday after leaving the loss to the Rams.
Head coach John Harbaugh left open the possibility Dart could return if New York makes the playoffs.
Sources told NFL Network that Dart's knee injury will require surgery, ending his season and reshaping New York's plans at quarterback.
New York's football fortunes take another hit as the team must adjust its plans following quarterback Jaxson Dart's season-ending injury.