Most of the casualties were reported in the Sheikh Radwan neighborhood and the Nuseirat refugee camp amid continued Israeli military activity.
The ministry also reported more than 12,400 people wounded, according to TASS.
The Hamas-run Gaza Health Ministry said five more Palestinians were killed in Israeli strikes, and reported the cumulative death toll since the war began has risen to 73,928.
The Gaza Health Ministry says three more Palestinians were killed, bringing the number of people injured since the start of the war to 174,995.
The Gaza Health Ministry reported 174,935 people injured since the war began on October 7, 2023.
Officials cite fuel, oil and spare-parts shortages linked to the ongoing Israeli blockade as threatening critical hospital departments across the territory.