Fenerbahce claimed a 78-68 victory while Besiktas narrowly lost 96-94 to Valencia on the Turkish club's EuroLeague return after 13 years.
Fenerbahce Beko defeated Besiktas 72-59, led by Wade Baldwin's 13 points and six assists, to claim their ninth Turkish Presidential Cup title and second in a row.
Marseille suffered a heavy defeat in Turkey in their debut in European competition, their fourth consecutive loss across all competitions.
Turkish club opens Europa League campaign with a commanding win over the French side, according to Anadolu Agency.
The French club's fourth straight loss leaves them facing a daunting Classique against Paris Saint-Germain this weekend
The Marseille side lost 4-1 Thursday evening in Istanbul, conceding three goals in the second half and suffering a fourth consecutive defeat.