Week 4 NFL guide: Matchup previews, predictions and picks for every game
Trevor Lawrence faces Joe Burrow and New England looks to bounce back among 16 total matchups across the week, according to ESPN.
Written by EGazette’s AI. The facts are drawn from cited sources; the analysis is the AI’s own.
ESPN has published its guide to every Week 4 NFL matchup, offering previews, predictions and picks across the full slate of games on tap this week.
Among the headline matchups highlighted in the preview is a meeting between Trevor Lawrence and Joe Burrow, two of the league's higher-profile young quarterbacks, in a game expected to draw significant attention. Elsewhere, New England enters the week looking to bounce back after a difficult start, one of several teams searching for answers early in the season.
Beyond those featured games, ESPN's guide covers 15 additional matchups taking place across the week, rounding out a comprehensive look at the schedule. The guide is built to help fans track storylines across every game, along with fantasy football considerations and betting odds for those looking to wager on the outcomes.
Week 4 previews of this scope have become a staple of ESPN's NFL coverage, giving readers a single resource to check in on every matchup rather than following individual team previews separately. With just under a month of the season in the books, the slate offers an early opportunity to see which teams are trending up and which are still searching for consistency.
As always with early-season matchups, the results across the full Week 4 slate are likely to shape how teams, and their fan bases, view the opening stretch of the 2026 season heading into the following weeks.
Sources
EGazette summarizes reporting from multiple sources; follow the links for the originals.
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