NFL Week 4 preview: Matchups, predictions and picks for every game
Trevor Lawrence meets Joe Burrow and New England looks to bounce back among a full slate of 16 games.
Written by EGazette’s AI. The facts are drawn from cited sources; the analysis is the AI’s own.

NFL Week 4 features a full slate of games, headlined by a matchup between quarterbacks Trevor Lawrence and Joe Burrow, as well as a New England team looking to bounce back after recent struggles.
The Lawrence-Burrow matchup draws particular attention given both quarterbacks' standing as top picks tasked with leading their respective franchises back toward sustained contention. Quarterback duels of this kind are often viewed as early barometers for how each team's season is shaping up, even though the final result depends on contributions well beyond the starting quarterbacks.
New England enters the week looking to right the ship after a difficult stretch, with the team's performance this week likely to shape the broader narrative around its season heading into the following weeks. Teams coming off disappointing results often face increased scrutiny over coaching decisions and personnel usage as they search for a turnaround.
Beyond these headline matchups, the full Week 4 slate includes a further 15 games across the league, each carrying its own playoff and divisional implications this early in the season. Analysts typically weigh recent form, injury reports, and matchup-specific factors such as offensive and defensive line play when previewing each contest.
With the full schedule set to unfold over the weekend, fans and bettors alike are looking to these matchups, along with the accompanying predictions and picks, to gauge how the league's competitive landscape is taking shape in the season's early weeks.
Sources
EGazette summarizes reporting from multiple sources; follow the links for the originals.
Comments
Loading comments…
Related articles
Fantasy football Week 4: What to know, including possible breakouts for Mariota and Tuten
A rundown of the key information and insight fantasy managers need ahead of Week 4 lineup decisions.
Fantasy football: Three hot starters to trust, plus one Week 4 breakout candidate
Analysts say several early-season standouts could keep producing, while a slow-starting quarterback may be due for a big week.
For Kyler Murray's future with the Vikings, the clock is already ticking
On a one-year deal with a no-tag clause, Murray and the Vikings are each sizing up the other as the season unfolds.
Are NFL quarterback injuries running above normal this season?
Eight quarterbacks have been hurt through the first three weeks, prompting debate over whether it's a trend or a statistical outlier.
Early look at the NFL trade deadline: candidates, teams to watch, predictions
With the Nov. 10 deadline still weeks away, analysts offer an early preview of possible movers and the clubs most likely to be active.
Mahomes, Chiefs Rediscover the Deep Ball as Passing Attack Improves
Patrick Mahomes has shown marked improvement on deep throws this season, completing more than half of his attempts on passes traveling 15 or more yards.